Laboratory of Malariology

Department of Infectious Diseases Control;

Subjects:

1. The evolution of antigen polymorphism in malaria parasites.
2. The origin and evolution of malaria parasites.
3. The evolution of the mitochondrial genome of Apicomplexa.
4. The prevalence and population dynamics of Plasmodium vivax in Africa.

Published Papers

1. Progress in the molecular biology of malaria and the immunology of nematode infections.

   Naoki Arizono, Kenji Nakanihsi, Toshihiro Horii and Kazuyuki Tanabe

   Trends Parasitol, 23 (4), 175-181, 2007.
2. Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites.

   Kazuyuki Tanabe, Ananias Escalante, Naoko Sakihama, Masanori Honda, Nobuko Arisue, Toshihiro Horii, Richard Culleton, Toshiyuki Hayakawa, Tetsuo Hashimoto, Shirley Longacre, Sisira Pathirana, Shiroma Handunnetti and Hirohisa Kishino

   Mol Biochem Parasitol, 156 (1), 74-79, 2007.
3. Allelic diversity in the merozoite surface protein 1 gene of Plasmodium falciparum on Palawan Island, the Philippines.

   Naoko Sakihama, Masatoshi Nakamura, Antonio A Palanca, Renee A Argubano, Ester P Realon, Alan L Larracas, Ronald L Espina and Kazuyuki Tanabe

   Parasitol Int, 56 (3), 185-194, 2007.
4. Allelic dimorphism-associated restriction of recombination in Plasmodium falciparum msp1.

   Kazuyuki Tanabe, Naoko Sakihama, David Walliker, Hamza Babiker, Abdel-Muhsin A Abdel-Muhsin, Bernard Bakote'e, Hiroshi Ohmae, Nobuko Arisue, Toshihiro Horii, Ingegerd Rooth, Anna Färnert, Anders Björkman and Lisa Ranford-Cartwright

   Gene, 397 (1-2), 153-160, 2007.
5. Production of high-affinity human monoclonal antibody fab fragments to the 19-kilodalton C-terminal merozoite surface protein 1 of Plasmodium falciparum.

   Xun-Jia Cheng, Hitoshi Hayasaka, Katsuomi Watanabe, Yan-Lin Tao, Jin-Ye Liu, Hideo Tsukamoto, Toshihiro Horii, Kazuyuki Tanabe and Hiroshi Tachibana

   Infect Immun, 75 (7), 3614-3620, 2007.
6. High frequency of recombination-driven allelic diversity and temporal variation of Plasmodium falciparum msp1 in Tanzania.

   Kazuyuki Tanabe, Naoko Sakihama, Ingegerd Rooth, Anders Björkman and Anna Färnert

   Am J Trop Med Hyg, 76 (6), 1037-1045, 2007.
7. Independent evolution of pyrimethamine resistance in Plasmodium falciparum isolates in Melanesia.

   Toshihiro Mita, Kazuyuki Tanabe, Nobuyuki Takahashi, Takahiro Tsukahara, Hideaki Eto, Lek Dysoley, Hiroshi Ohmae, Kiyoshi Kita, Srivicha Krudsood, Sornchai Looareesuwan, Akira Kaneko, Anders Björkman and Takatoshi Kobayakawa

   Antimicrob Agents Chemother, 51 (3), 1071-1077, 2007.
8. A comparative study of the genetic diversity of the 42kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P. vivax.

   M Andreina Pacheco, Amanda C Poe, William E Collins, Altaf A Lal, Kazuyuki Tanabe, Simon K Kariuki, Venkatachalam Udhayakumar and Ananias A Escalante

   Infect Genet Evol, 7 (2), 180-187, 2007.
9. Human-specific expression of Siglec-6 in the placenta.

   Els C M Brinkman-Van der Linden, Nancy Hurtado-Ziola, Toshiyuki Hayakawa, Lisa Wiggleton, Kurt Benirschke, Ajit Varki and Nissi Varki

   Glycobiology, 17 (9), 922-931, 2007.
10. An Alu retrotransposition-mediated deletion of CHD7 in a patient with CHARGE syndrome.

    Toru Udaka, Nobuhiko Okamoto, Michihiko Aramaki, Chiharu Torii, Rika Kosaki, Noboru Hosokai, Toshiyuki Hayakawa, Naoyuki Takahata, Takao Takahashi and Kenjiro Kosaki

    Am J Med Genet A, 143 (7), 721-726, 2007.
11. Immunostimulating effects of the polyphenol-rich fraction of sugar cane (Saccharum officinarum L.) extract in chickens.

    Kenji Hikosaka, Moshira El-Abasy, Yukari Koyama, Maki Motobu, Kenji Koge, Takashi Isobe, Chung-Boo Kang, Hideki Hayashidani, Takashi Onodera, Pi-Chao Wang, Masatoshi Matsumura and Yoshikazu Hirota

    Phytother Res, 21 (2), 120-125, 2007.
12. Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites.

    Paul Hunt, Ana Afonso, Alison Creasey, Richard Culleton, Amar Bir Singh Sidhu, John Logan, Stephanie G Valderramos, Iain McNae, Sandra Cheesman, Virgilio do Rosario, Richard Carter, David A Fidock and Pedro Cravo

    Mol Microbiol, 65 (1), 27-40, 2007.

Link

http://www.biken.osaka-u.ac.jp/