Department of Host Defense

Subjects:

1. Physiological roles of Toll-like receptor family and signaling pathways via TLRs.
2. Pathogen recognition mechanisms by innate immune system.

Published Papers

1. Toll-like receptors.

   Kiyoshi Takeda and Shizuo Akira

   Curr Protoc Immunol, Chapter 14, Unit 14.12, 2007.
2. Signaling to NF-kappaB by Toll-like receptors.

   Taro Kawai and Shizuo Akira

   Trends Mol Med, 13 (11), 460-469, 2007.
3. Deletion of TLR5 results in spontaneous colitis in mice.

   Matam Vijay-Kumar, Catherine J Sanders, Rebekah T Taylor, Amrita Kumar, Jesse D Aitken, Shanthi V Sitaraman, Andrew S Neish, Satoshi Uematsu, Shizuo Akira, Ifor R Williams and Andrew T Gewirtz

   J Clin Invest, 117 (12), 3909-3921, 2007.
4. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.

   Pamela Gasse, Caroline Mary, Isabelle Guenon, Nicolas Noulin, Sabine Charron, Silvia Schnyder-Candrian, Bruno Schnyder, Shizuo Akira, Valérie F J Quesniaux, Vincent Lagente, Bernhard Ryffel and Isabelle Couillin

   J Clin Invest, 117 (12), 3786-3799, 2007.
5. Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.

   Thomas R Hawn, William R Berrington, Ian A Smith, Satoshi Uematsu, Shizuo Akira, Alan Aderem, Kelly D Smith and Shawn J Skerrett

   J Immunol, 179 (10), 6981-6987, 2007.
6. Recognition of viruses by innate immunity.

   Osamu Takeuchi and Shizuo Akira

   Immunol Rev, 220, 214-224, 2007.
7. The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.

   Noula Shembade, Nicole S Harhaj, Masahiro Yamamoto, Shizuo Akira and Edward W Harhaj

   J Virol, 81 (24), 13735-13742, 2007.
8. The C/EBPbeta Isoform 34-kDa LAP Is Responsible for NF-IL-6-Mediated Gene Induction in Activated Macrophages, but Is Not Essential for Intracellular Bacteria Killing.

   Satoshi Uematsu, Tsuneyasu Kaisho, Takashi Tanaka, Makoto Matsumoto, Megumi Yamakami, Hiroko Omori, Masahiro Yamamoto, Tamotsu Yoshimori and Shizuo Akira

   J Immunol, 179 (8), 5378-5386, 2007.
9. Genetic analysis of resistance to viral infection.

   Bruce Beutler, Celine Eidenschenk, Karine Crozat, Jean-Luc Imler, Osamu Takeuchi, Jules A Hoffmann and Shizuo Akira

   Nat Rev Immunol, 7 (10), 753-766, 2007.
10. IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc{varepsilon}RI signals.

    Lien H Ho, Tatsukuni Ohno, Keisuke Oboki, Naoki Kajiwara, Hajime Suto, Motoyasu Iikura, Yoshimichi Okayama, Shizuo Akira, Hirohisa Saito, Stephen J Galli and Susumu Nakae

    J Leukoc Biol, 82 (6), 1481-1490, 2007.
11. Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination.

    Shohei Koyama, Ken J Ishii, Himanshu Kumar, Takeshi Tanimoto, Cevayir Coban, Satoshi Uematsu, Taro Kawai and Shizuo Akira

    J Immunol, 179 (7), 4711-4720, 2007.
12. Calcineurin Negatively Regulates TLR-Mediated Activation Pathways.

    Young Jun Kang, Brenda Kusler, Motoyuki Otsuka, Michael Hughes, Nobutaka Suzuki, Shinobu Suzuki, Wen-Chen Yeh, Shizuo Akira, Jiahuai Han and Patricia P Jones

    J Immunol, 179 (7), 4598-4607, 2007.
13. Modified vaccinia virus Ankara induces Toll-like receptor independent type I interferon responses.

    Zoe Waibler, Martina Anzaghe, Holger Ludwig, Shizuo Akira, Siegfried Weiss, Gerd Sutter and Ulrich Kalinke

    J Virol, 81 (22), 12102-12110, 2007.
14. Short dysfunctional telomeres impair the repair of arsenite-induced oxidative damage in mouse cells.

    Jennifer P A Newman, Birendranath Banerjee, Wanru Fang, Anuradha Poonepalli, Lakshmidevi Balakrishnan, Grace Kah Mun Low, Rabindra N Bhattacharjee, Shizuo Akira, Manikandan Jayapal, Alirio J Melendez, Rajamanickam Baskar, Han-Woong Lee and M Prakash Hande

    J Cell Physiol, 214 (3), 796-809, 2007.
15. Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance.

    Subhra K Biswas, Pradeep Bist, Manprit Kaur Dhillon, Tasneem Kajiji, Carlos Del Fresno, Masahiro Yamamoto, Eduardo Lopez-Collazo, Shizuo Akira and Vinay Tergaonkar

    J Immunol, 179 (6), 4083-4092, 2007.
16. TLR9 is required for protective innate immunity in Gram-negative bacterial pneumonia: role of dendritic cells.

    Urvashi Bhan, Nicholas W Lukacs, John J Osterholzer, Michael W Newstead, Xianying Zeng, Thomas A Moore, Tracy R McMillan, Arthur M Krieg, Shizuo Akira and Theodore J Standiford

    J Immunol, 179 (6), 3937-3946, 2007.
17. Nitrogen dioxide promotes allergic sensitization to inhaled antigen.

    Mieke Bevelander, Jana Mayette, Laurie A Whittaker, Sara A Paveglio, Christine C Jones, Justin Robbins, David Hemenway, Shizuo Akira, Satoshi Uematsu and Matthew E Poynter

    J Immunol, 179 (6), 3680-3688, 2007.
18. FADD negatively regulates lipopolysaccharide signaling by impairing IRAK1-MyD88 interaction.

    Rachel Zhande, Shauna M Dauphinee, James A Thomas, Masahiro Yamamoto, Shizuo Akira and Aly Karsan

    Mol Cell Biol, 27 (21), 7394-7404, 2007.
19. Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.

    Masahiro Yamamoto, Satoshi Uematsu, Toru Okamoto, Yoshiharu Matsuura, Shintaro Sato, Himanshu Kumar, Takashi Satoh, Tatsuya Saitoh, Kiyoshi Takeda, Ken J Ishii, Osamu Takeuchi, Taro Kawai and Shizuo Akira

    J Exp Med, 204 (9), 2233-2239, 2007.
20. Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.

    Yutaro Kumagai, Osamu Takeuchi, Hiroki Kato, Himanshu Kumar, Kosuke Matsui, Eiichi Morii, Katsuyuki Aozasa, Taro Kawai and Shizuo Akira

    Immunity, 27 (2), 240-252, 2007.
21. Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells.

    Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira and Toshiaki Ohteki

    Nature, 448 (7156), 929-933, 2007.
22. The Atg5 Atg12 conjugate associates with innate antiviral immune responses.

    Nao Jounai, Fumihiko Takeshita, Kouji Kobiyama, Asako Sawano, Atsushi Miyawaki, Ke-Qin Xin, Ken J Ishii, Taro Kawai, Shizuo Akira, Koichi Suzuki and Kenji Okuda

    Proc Natl Acad Sci U S A, 104 (35), 14050-14055, 2007.
23. Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes.

    Hun Sik Kim, Myoung Sook Han, Kun Wook Chung, Sunshin Kim, Eunshil Kim, Myoung Joo Kim, Eunkyeong Jang, Hyun Ah Lee, Jeehee Youn, Shizuo Akira and Myung-Shik Lee

    Immunity, 27 (2), 321-333, 2007.
24. Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice.

    Ryotaro Sakamori, Tetsuo Takehara, Chihiro Ohnishi, Tomohide Tatsumi, Kazuyoshi Ohkawa, Kiyoshi Takeda, Shizuo Akira and Norio Hayashi

    Hepatology, 46 (5), 1564-1573, 2007.
25. Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself.

    Jiali Li, Wenru Song, Debra K Czerwinski, Bindu Varghese, Satoshi Uematsu, Shizuo Akira, Arthur M Krieg and Ronald Levy

    J Immunol, 179 (4), 2493-2500, 2007.
26. MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus.

    Karl S Lang, Alexander A Navarini, Mike Recher, Philipp A Lang, Mathias Heikenwalder, Barbara Stecher, Andreas Bergthaler, Bernhard Odermatt, Shizuo Akira, Kenya Honda, Hans Hengartner and Rolf M Zinkernagel

    Eur J Immunol, 37 (9), 2434-2440, 2007.
27. Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors.

    Jin-Hwan Han, Shizuo Akira, Kathryn Calame, Bruce Beutler, Erik Selsing and Thereza Imanishi-Kari

    Immunity, 27 (1), 64-75, 2007.
28. IL-3 is an important differentiation factor for the development of prostaglandin E2-producing macrophages between C57BL/6 and BALB/c mice.

    Etsushi Kuroda, Junko Noguchi, Takahiro Doi, Satoshi Uematsu, Sizuo Akira and Uki Yamashita

    Eur J Immunol, 37 (8), 2185-2195, 2007.
29. Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine.

    Sukumar Saha, Fumihiko Takeshita, Tomoko Matsuda, Nao Jounai, Kouji Kobiyama, Tetsuya Matsumoto, Shin Sasaki, Atsushi Yoshida, Ke-Qin Xin, Dennis M Klinman, Satoshi Uematsu, Ken J Ishii, Shizuo Akira and Kenji Okuda

    J Immunol, 179 (2), 1147-1154, 2007.
30. ER stress triggers apoptosis by activating BH3-only protein Bim.

    Hamsa Puthalakath, Lorraine A O'Reilly, Priscilla Gunn, Lily Lee, Priscilla N Kelly, Nicholas D Huntington, Peter D Hughes, Ewa M Michalak, Jennifer McKimm-Breschkin, Noburo Motoyama, Tomomi Gotoh, Shizuo Akira, Philippe Bouillet and Andreas Strasser

    Cell, 129 (7), 1337-1349, 2007.
31. Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.

    Fumiyo Ikeda, Christina Maria Hecker, Alexis Rozenknop, Rolf Dietrich Nordmeier, Vladimir Rogov, Kay Hofmann, Shizuo Akira, Volker Dötsch and Ivan Dikic

    EMBO J, 26 (14), 3451-3462, 2007.
32. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.

    Chun-Jen Chen, Hajime Kono, Douglas Golenbock, George Reed, Shizuo Akira and Kenneth L Rock

    Nat Med, 13 (7), 851-856, 2007.
33. Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines.

    Takayuki Abe, Yuuki Kaname, Itsuki Hamamoto, Yoshimi Tsuda, Xiaoyu Wen, Shuhei Taguwa, Kohji Moriishi, Osamu Takeuchi, Taro Kawai, Tatsuya Kanto, Norio Hayashi, Shizuo Akira and Yoshiharu Matsuura

    J Virol, 81 (17), 8953-8966, 2007.
34. The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.

    Zachary J Roberts, Nadege Goutagny, Pin-Yu Perera, Hiroki Kato, Himanshu Kumar, Taro Kawai, Shizuo Akira, Ram Savan, David van Echo, Katherine A Fitzgerald, Howard A Young, Lai-Ming Ching and Stefanie N Vogel

    J Exp Med, 204 (7), 1559-1569, 2007.
35. SnapShot: Pattern-recognition receptors.

    Taro Kawai and Shizuo Akira

    Cell, 129 (5), 1024, 2007.
36. A polysaccharide carrier to effectively deliver native phosphodiester CpG DNA to antigen-presenting cells.

    Naohiko Shimada, Cevayir Coban, Yoichi Takeda, Masami Mizu, Jusaku Minari, Takahisa Anada, Yuichi Torii, Seiji Shinkai, Shizuo Akira, Ken J Ishii and Kazuo Sakurai

    Bioconjug Chem, 18 (4), 1280-1286, 2007.
37. Toll-like receptors and chondrocytes: the lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7.

    K Bobacz, I G Sunk, J G Hofstaetter, L Amoyo, C D Toma, S Akira, T Weichhart, M Saemann and J S Smolen

    Arthritis Rheum, 56 (6), 1880-1893, 2007.
38. Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production.

    Kei Yasuda, Christophe Richez, Joseph W Maciaszek, Neerja Agrawal, Shizuo Akira, Ann Marshak-Rothstein and Ian R Rifkin

    J Immunol, 178 (11), 6876-6885, 2007.
39. Cutting edge: TLR2 directly triggers Th1 effector functions.

    Takayuki Imanishi, Hiromitsu Hara, Shinobu Suzuki, Nobutaka Suzuki, Shizuo Akira and Takashi Saito

    J Immunol, 178 (11), 6715-6719, 2007.
40. Immunogenicity and protective efficacy offered by a ribosomal-based vaccine from Shigella flexneri 2a.

    Doo-Hee Shim, Sun-Young Chang, Sung-Moo Park, Hyun Jang, Rodney Carbis, Cecil Czerkinsky, Satoshi Uematsu, Shizuo Akira and Mi-Na Kweon

    Vaccine, 25 (25), 4828-4836, 2007.
41. Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice.

    Ganesan Ramesh, Binzhi Zhang, Satoshi Uematsu, Shizuo Akira and W Brian Reeves

    Am J Physiol Renal Physiol, 293 (1), F325-332, 2007.
42. Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif.

    Pamela Cook, Sabine Tötemeyer, Catherine Stevenson, Katherine A Fitzgerald, Masahiro Yamamoto, Shizuo Akira, Duncan J Maskell and Clare E Bryant

    Immunology, 122 (2), 222-229, 2007.
43. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling.

    Tatsukata Kawagoe, Shintaro Sato, Andreas Jung, Masahiro Yamamoto, Kosuke Matsui, Hiroki Kato, Satoshi Uematsu, Osamu Takeuchi and Shizuo Akira

    J Exp Med, 204 (5), 1013-1024, 2007.
44. Manipulation of host innate immune responses by the malaria parasite.

    Cevayir Coban, Ken J Ishii, Toshihiro Horii and Shizuo Akira

    Trends Microbiol, 15 (6), 271-278, 2007.
45. Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection.

    Erica Andersen-Nissen, Thomas R Hawn, Kelly D Smith, Alex Nachman, Aaron E Lampano, Satoshi Uematsu, Shizuo Akira and Alan Aderem

    J Immunol, 178 (8), 4717-4720, 2007.
46. Toll-like receptors and Type I interferons.

    Satoshi Uematsu and Shizuo Akira

    J Biol Chem, 282 (21), 15319-15323, 2007.
47. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.

    Michaela U Gack, Young C Shin, Chul-Hyun Joo, Tomohiko Urano, Chengyu Liang, Lijun Sun, Osamu Takeuchi, Shizuo Akira, Zhijian Chen, Satoshi Inoue and Jae U Jung

    Nature, 446 (7138), 916-920, 2007.
48. Toll or toll-free adjuvant path toward the optimal vaccine development.

    Ken J Ishii and Shizuo Akira

    J Clin Immunol, 27 (4), 363-371, 2007.
49. NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

    Sinead M Miggin, Eva Pålsson-McDermott, Aisling Dunne, Caroline Jefferies, Emmanuel Pinteaux, Kathy Banahan, Caroline Murphy, Paul Moynagh, Masahiro Yamamoto, Shizuo Akira, Nancy Rothwell, Douglas Golenbock, Katherine A Fitzgerald and Luke A J O'Neill

    Proc Natl Acad Sci U S A, 104 (9), 3372-3377, 2007.
50. A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity.

    Donghoon Kim, Myung Ah Kim, Ik-Hyun Cho, Mi Sun Kim, Soojin Lee, Eun-Kyeong Jo, Se-Young Choi, Kyungpyo Park, Joong Soo Kim, Shizuo Akira, Heung Sik Na, Seog Bae Oh and Sung Joong Lee

    J Biol Chem, 282 (20), 14975-14983, 2007.
51. Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori.

    Marygorret Obonyo, Mojgan Sabet, Sheri P Cole, Joerg Ebmeyer, Satoshi Uematsu, Shizuo Akira and Donald G Guiney

    Infect Immun, 75 (5), 2408-2414, 2007.
52. Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population.

    Kayoko Tao, Mutsuko Fujii, Shin-ichi Tsukumo, Yoichi Maekawa, Kenji Kishihara, Yasutaka Kimoto, Takahiko Horiuchi, Hajime Hisaeda, Shizuo Akira, Shoji Kagami and Koji Yasutomo

    Ann Rheum Dis, 66 (7), 905-909, 2007.
53. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses.

    Kishore R Alugupalli, Shizuo Akira, Egil Lien and John M Leong

    J Immunol, 178 (6), 3740-3749, 2007.
54. A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-beta in the host response to Pseudomonas aeruginosa lung infection in mice.

    Melanie R Power, Bo Li, Masahiro Yamamoto, Shizuo Akira and Tong-Jun Lin

    J Immunol, 178 (5), 3170-3176, 2007.
55. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia.

    Samithamby Jeyaseelan, Scott K Young, Michael B Fessler, Yuhong Liu, Kenneth C Malcolm, Masahiro Yamamoto, Shizuo Akira and G Scott Worthen

    J Immunol, 178 (5), 3153-3160, 2007.
56. Signaling pathways activated by microorganisms.

    Osamu Takeuchi and Shizuo Akira

    Curr Opin Cell Biol, 19 (2), 185-191, 2007.
57. Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo.

    Svetlana Hamm, Antje Heit, Martina Koffler, Katharina M Huster, Shizuo Akira, Dirk H Busch, Herrmann Wagner and Stefan Bauer

    Int Immunol, 19 (3), 297-304, 2007.
58. Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways.

    Junko Sawaki, Hiroko Tsutsui, Nobuki Hayashi, Koubun Yasuda, Shizuo Akira, Takakuni Tanizawa and Kenji Nakanishi

    Int Immunol, 19 (3), 311-320, 2007.
59. TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses.

    Alex K Heer, Abdijapar Shamshiev, Alena Donda, Satoshi Uematsu, Shizuo Akira, Manfred Kopf and Benjamin J Marsland

    J Immunol, 178 (4), 2182-2191, 2007.
60. TLR signaling.

    Taro Kawai and Shizuo Akira

    Semin Immunol, 19 (1), 24-32, 2007.
61. Interleukin-18 regulates pathological intraocular neovascularization.

    Hong Qiao, Koh-Hei Sonoda, Yasuhiro Ikeda, Takeru Yoshimura, Kuniaki Hijioka, Young-Joon Jo, Yukio Sassa, Chikako Tsutsumi-Miyahara, Yasuaki Hata, Shizuo Akira and Tatsuro Ishibashi

    J Leukoc Biol, 81 (4), 1012-1021, 2007.
62. Viral infections activate types I and III interferon genes through a common mechanism.

    Kazuhide Onoguchi, Mitsutoshi Yoneyama, Azumi Takemura, Shizuo Akira, Tadatsugu Taniguchi, Hideo Namiki and Takashi Fujita

    J Biol Chem, 282 (10), 7576-7581, 2007.
63. Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification.

    Jianhong Yao, Tae Whan Kim, Jinzhong Qin, Zhengfan Jiang, Youcun Qian, Hui Xiao, Yi Lu, Wen Qian, Muhammet Fatih Gulen, Nywana Sizemore, Joseph DiDonato, Shintaro Sato, Shizuo Akira, Bing Su and Xiaoxia Li

    J Biol Chem, 282 (9), 6075-6089, 2007.
64. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.

    Takeshi Saito, Reiko Hirai, Yueh-Ming Loo, David Owen, Cynthia L Johnson, Sangita C Sinha, Shizuo Akira, Takashi Fujita and Michael Gale

    Proc Natl Acad Sci U S A, 104 (2), 582-587, 2007.
65. Antiviral signaling through pattern recognition receptors.

    Taro Kawai and Shizuo Akira

    J Biochem (Tokyo), 141 (2), 137-145, 2007.
66. Toll-like receptor 2 does not contribute to host response during postinfluenza pneumococcal pneumonia.

    Mark C Dessing, Koenraad F van der Sluijs, Sandrine Florquin, Shizuo Akira and Tom van der Poll

    Am J Respir Cell Mol Biol, 36 (5), 609-614, 2007.
67. Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans.

    Shinobu Saijo, Noriyuki Fujikado, Takahisa Furuta, Soo-hyun Chung, Hayato Kotaki, Keisuke Seki, Katsuko Sudo, Shizuo Akira, Yoshiyuki Adachi, Naohito Ohno, Takeshi Kinjo, Kiwamu Nakamura, Kazuyoshi Kawakami and Yoichiro Iwakura

    Nat Immunol, 8 (1), 39-46, 2007.
68. Pathological role of Toll-like receptor signaling in cerebral malaria.

    Cevayir Coban, Ken J Ishii, Satoshi Uematsu, Nobuko Arisue, Shintaro Sato, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi, Hajime Hisaeda, Toshihiro Horii and Shizuo Akira

    Int Immunol, 19 (1), 67-79, 2007.
69. Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.

    Barbara Albiger, Sofia Dahlberg, Andreas Sandgren, Florian Wartha, Katharina Beiter, Hiroaki Katsuragi, Shizuo Akira, Staffan Normark and Birgitta Henriques-Normark

    Cell Microbiol, 9 (3), 633-644, 2007.
70. Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.

    Luisa Cervantes-Barragan, Roland Züst, Friedemann Weber, Martin Spiegel, Karl S Lang, Shizuo Akira, Volker Thiel and Burkhard Ludewig

    Blood, 109 (3), 1131-1137, 2007.
71. Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury.

    Yasushi Sakata, Jian-Wen Dong, Jesus G Vallejo, Chien-Hua Huang, J Scott Baker, Kevin J Tracey, Osamu Tacheuchi, Shizuo Akira and Douglas L Mann

    Am J Physiol Heart Circ Physiol, 292 (1), H503-509, 2007.
72. Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2.

    Chul-Su Yang, Ji-Sook Lee, Chang-Hwa Song, Gang Min Hur, Sung Joong Lee, Sakae Tanaka, Shizuo Akira, Tae-Hyun Paik and Eun-Kyeong Jo

    Cell Microbiol, 9 (2), 382-396, 2007.

Link

http://www.biken.osaka-u.ac.jp/