Department of Molecular Genetics

Subjects:

1. Molecular mechanisms regulating the cell cycle in mammalian cells.
2. Molecular mechanisms controlling the meiosis in fission yeast.
3. Molecular mechanisms modulating the metastasis of malignant cells.
4. Application of a new technique (stepwise subtraction) to RNA diagnosis.

Published Papers

1. Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients.

   Nobuo Nakamura, Yasunori Shimaoka, Takahiro Tougan, Hiroaki Onda, Daisuke Okuzaki, Hanjun Zhao, Azumi Fujimori, Norikazu Yabuta, Ippei Nagamori, Akie Tanigawa, Jun Sato, Takenori Oda, Kenji Hayashida, Ryuji Suzuki, Masao Yukioka, Hiroshi Nojima and Takahiro Ochi

   DNA Res, 13 (4), 169-183, 2006.
2. A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.

   Yael Aylon, Dan Michael, Ayelet Shmueli, Norikazu Yabuta, Hiroshi Nojima and Moshe Oren

   Genes Dev, 20 (19), 2687-2700, 2006.
3. The testes-specific bZip type transcription factor Tisp40 plays a role in ER stress responses and chromatin packaging during spermiogenesis.

   Ippei Nagamori, Kentaro Yomogida, Masahito Ikawa, Masaru Okabe, Norikazu Yabuta and Hiroshi Nojima

   Genes Cells, 11 (10), 1161-1171, 2006.
4. Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest.

   Norikazu Yabuta, Hiroaki Onda, Masafumi Watanabe, Naohisa Yoshioka, Ippei Nagamori, Tomoyuki Funatsu, Shingo Toji, Katsuyuki Tamai and Hiroshi Nojima

   Nucleic Acids Res, 34 (17), 4878-4892, 2006.
5. Spo5/Mug12, a putative meiosis-specific RNA-binding protein, is essential for meiotic progression and forms Mei2 dot-like nuclear foci.

   Takashi Kasama, Akira Shigehisa, Aiko Hirata, Takamune T Saito, Takahiro Tougan, Daisuke Okuzaki and Hiroshi Nojima

   Eukaryot Cell, 5 (8), 1301-1313, 2006.
6. RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation.

   Hanjun Zhao, Akihiko Ito, Naohiko Sakai, Yuji Matsuzawa, Shizuya Yamashita and Hiroshi Nojima

   Circ J, 70 (5), 615-624, 2006.
7. RECS1 deficiency in mice induces susceptibility to cystic medial degeneration.

   Hanjun Zhao, Akihiko Ito, Shinya H Kimura, Norikazu Yabuta, Naohiko Sakai, Masahito Ikawa, Masaru Okabe, Yuji Matsuzawa, Shizuya Yamashita and Hiroshi Nojima

   Genes Genet Syst, 81 (1), 41-50, 2006.
8. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

   P Mathijs Voorhoeve, Carlos le Sage, Mariette Schrier, Ad J M Gillis, Hans Stoop, Remco Nagel, Ying-Poi Liu, Josyanne van Duijse, Jarno Drost, Alexander Griekspoor, Eitan Zlotorynski, Norikazu Yabuta, Gabriella De Vita, Hiroshi Nojima, Leendert H J Looijenga and Reuven Agami

   Cell, 124 (6), 1169-1181, 2006.
9. Mcp5, a meiotic cell cortex protein, is required for nuclear movement mediated by dynein and microtubules in fission yeast.

   Takamune T Saito, Daisuke Okuzaki and Hiroshi Nojima

   J Cell Biol, 173 (1), 27-33, 2006.
10. Transcription factors CREM and Tisp40 act in concert in post-meiotic transcriptional regulation.

    Ippei Nagamori, Kentaro Yomgida, Peter Adams, Paolo Sassone-Corsi and Hiroshi Nojima

    J Biol Chem, 281 (22), 15073-15081, 2006.
11. The testes-specific bZip type transcription factor Tisp40 plays a role in ER stress responses and chromatin packaging during spermiogenesis.

    Ippei Nagamori, Kentaro Yomogida, Masahito Ikawa, Masaru Okabe, Norikazu Yabuta and Hiroshi Nojima

    Genes Cells, 11 (10), 1161-1171, 2006.

Link

http://www.biken.osaka-u.ac.jp/