Department of Virology

Subjects:

1. Pathogenesis of human immunodeficiency virus type 1.
2. Epidemiological, virological and molecular-biological characterization of Borna disease virus.
3. Mechanism of prion-induced pathogenesis in model systems.
4. Pathogenesis of SARS-coronavirus and influenzavirus.

Published Papers

1. Inactivation of parvovirus B19 by liquid heating incorporated in the manufacturing process of human intravenous immunoglobulin preparations.

   Mikihiro Yunoki, Takeru Urayama, Muneo Tsujikawa, Yoshie Sasaki, Shunichi Abe, Kazuo Takechi and Kazuyoshi Ikuta

   Br J Haematol, 128 (3), 401-404, 2005.
2. Octapeptide repeat region and N-terminal half of hydrophobic region of prion protein (PrP) mediate PrP-dependent activation of superoxide dismutase.

   Akikazu Sakudo, Deug-chan Lee, Takuya Nishimura, Shuming Li, Shoutaro Tsuji, Toyoo Nakamura, Yoshitsugu Matsumoto, Keiichi Saeki, Shigeyoshi Itohara, Kazuyoshi Ikuta and Takashi Onodera

   Biochem Biophys Res Commun, 326 (3), 600-606, 2005.
3. PrP cooperates with STI1 to regulate SOD activity in PrP-deficient neuronal cell line.

   Akikazu Sakudo, Deug-chan Lee, Shuming Li, Toyoo Nakamura, Yoshitsugu Matsumoto, Keiichi Saeki, Shigeyoshi Itohara, Kazuyoshi Ikuta and Takashi Onodera

   Biochem Biophys Res Commun, 328 (1), 14-19, 2005.
4. Persistent borna disease virus infection confers instability of HSP70 mRNA in glial cells during heat stress.

   Makiko Yamashita, Wataru Kamitani, Hideyuki Yanai, Naohiro Ohtaki, Yohei Watanabe, Byeong-Jae Lee, Shoutaro Tsuji, Kazuyoshi Ikuta and Keizo Tomonaga

   J Virol, 79 (4), 2033-2041, 2005.
5. Higher frequency of premature stop codon mutations at vpu gene of human immunodeficiency virus type 1 CRF01_AE compared with those of other subtypes.

   Satoshi Komoto, Shoutaro Tsuji, Byong-Jae Lee, Yukie Iwabu, Yoko Kojima, Toru Otake, Koki Taniguchi and Kazuyoshi Ikuta

   Microbes Infect, 7 (2), 139-147, 2005.
6. Different susceptibility of human immunodeficiency virus type 1 to Env gp41-derived synthetic peptides corresponding to the C-terminal heptad repeat region.

   Panasda Isarangkura N A, Gui-Mei Li, Jiranan Warachit, Yukie Iwabu, Shoutaro Tsuji, Wattana Auwanit, Daisuke Yamamoto, Toshiyuki Goto, Yoshio Hayashi, Yoshiaki Kiso and Kazuyoshi Ikuta

   Microbes Infect, 7 (3), 356-364, 2005.
7. Interleukin-4 up-regulates T-tropic human immunodeficiency virus type 1 transcription in primary CD4+ CD38+ T-lymphocyte subset.

   Yong-Gang Li, Yukie Iwabu, Jiranan Warachit, Masanobu Kinomoto, Madiha S Ibrahim, Shoutaro Tsuji, Tetsu Mukai, Masanori Kameoka, Kenzo Tokunaga, Tetsutaro Sata and Kazuyoshi Ikuta

   Microbiol Immunol, 49 (2), 155-165, 2005.
8. Amino acid 36 in the human immunodeficiency virus type 1 gp41 ectodomain controls fusogenic activity: implications for the molecular mechanism of viral escape from a fusion inhibitor.

   Masanobu Kinomoto, Masaru Yokoyama, Hironori Sato, Asato Kojima, Takeshi Kurata, Kazuyoshi Ikuta, Tetsutaro Sata and Kenzo Tokunaga

   J Virol, 79 (10), 5996-6004, 2005.
9. Susceptibility of human and rat neural cell lines to infection by SARS-coronavirus.

   Makiko Yamashita, Masanobu Yamate, Gui-Mei Li and Kazuyoshi Ikuta

   Biochem Biophys Res Commun, 334 (1), 79-85, 2005.
10. L565M mutation in HIV-1 glycoprotein 41 stabilizes the coiled-coil structure.

    Daisuke Yamamoto, Gui-Mei Li, Kazuyoshi Ikuta and Toshiyuki Goto

    Biochem Biophys Res Commun, 335 (1), 112-116, 2005.
11. Cell-autonomous PrP-Doppel interaction regulates apoptosis in PrP gene-deficient neuronal cells.

    Akikazu Sakudo, Deug-chan Lee, Izuru Nakamura, Yojiro Taniuchi, Keiichi Saeki, Yoshitsugu Matsumoto, Shigeyoshi Itohara, Kazuyoshi Ikuta and Takashi Onodera

    Biochem Biophys Res Commun, 333 (2), 448-454, 2005.
12. Enzootic intranasal tumour virus infection in apparently healthy sheep in Japan.

    K Kawasako, M Okamoto, T Kurosawa, T Nakade, R Kirisawa, T Miyashou, M Komine, T Go, S Imazu, N Takeuchi, K Tomonaga, K Ikuta, Y Akihara, Y Shimoyama, K Hirayama and H Taniyama

    Vet Rec, 157 (4), 118-120, 2005.
13. A novel diagnostic method for human immunodeficiency virus type-1 in plasma by near-infrared spectroscopy.

    Akikazu Sakudo, Roumiana Tsenkova, Taisuke Onozuka, Kazuo Morita, Shuming Li, Jiranan Warachit, Yukie Iwabu, Guimei Li, Takashi Onodera and Kazuyoshi Ikuta

    Microbiol Immunol, 49 (7), 695-701, 2005.
14. Poly(ADP-ribose)polymerase-1 is required for integration of the human immunodeficiency virus type 1 genome near centromeric alphoid DNA in human and murine cells.

    Masanori Kameoka, Souichi Nukuzuma, Asako Itaya, Yasuharu Tanaka, Katsuya Ota, Yoshiaki Inada, Kazuyoshi Ikuta and Koichiro Yoshihara

    Biochem Biophys Res Commun, 334 (2), 412-417, 2005.
15. Detection by radioligand assay of antibodies against Borna disease virus in patients with various psychiatric disorders.

    Hidenori Matsunaga, Susumu Tanaka, Fuyoko Sasao, Yoshii Nishino, Masatoshi Takeda, Keizo Tomonaga, Kazuyoshi Ikuta and Nobuyuki Amino

    Clin Diagn Lab Immunol, 12 (5), 671-676, 2005.
16. Preparation of monoclonal antibodies cross-reactive with orthopoxviruses and their application for direct immunofluorescence test.

    Noritoshi Kitamoto, Takayuki Kobayashi, Yoji Kato, Nobutaka Wakamiya, Kazuyoshi Ikuta, Tomoyuki Tanaka, Shigeharu Ueda, Hiroyuki Miyamoto and Shiro Kato

    Microbiol Immunol, 49 (3), 219-225, 2005.
17. Establishment of Vero E6 cell clones persistently infected with severe acute respiratory syndrome coronavirus.

    Masanobu Yamate, Makiko Yamashita, Toshiyuki Goto, Shoutaro Tsuji, Yong-Gang Li, Jiranan Warachit, Mikihiro Yunoki and Kazuyoshi Ikuta

    Microbes Infect, 7 (15), 1530-1540, 2005.

Link

http://www.biken.osaka-u.ac.jp/