Department of Signal Transduction

Subjects:

1. Analysis on the spatio-temporal regulation of Ras-superfamily G protein.
2. Development of probes for the visualization of the growth signal transduction cascade.
3. Spatio-temporal analysis on the activity of small G proteins during neuronal morphogenesis.
4. Computational modeling of signaling pathways upon growth factor stimulation

Published Papers

1. A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes.

   Reina E Itoh, Kazuo Kurokawa, Aki Fujioka, Alok Sharma, Bruce J Mayer and Michiyuki Matsuda

   Exp Cell Res, 307 (1), 142-152, 2005.
2. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction.

   Satoshi Uematsu, Shintaro Sato, Masahiro Yamamoto, Tomonori Hirotani, Hiroki Kato, Fumihiko Takeshita, Michiyuki Matsuda, Cevayir Coban, Ken J Ishii, Taro Kawai, Osamu Takeuchi and Shizuo Akira

   J Exp Med, 201 (6), 915-923, 2005.
3. Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.

   Kazuhiro Aoki, Takeshi Nakamura, Keiko Fujikawa and Michiyuki Matsuda

   Mol Biol Cell, 16 (5), 2207-2217, 2005.
4. Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.

   Kenta Terai and Michiyuki Matsuda

   EMBO Rep, 6 (3), 251-255, 2005.
5. Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions.

   Taihei Fukuyama, Hisakazu Ogita, Tomomi Kawakatsu, Tatsuro Fukuhara, Tomohiro Yamada, Tatsuhiro Sato, Kazuya Shimizu, Takeshi Nakamura, Michiyuki Matsuda and Yoshimi Takai

   J Biol Chem, 280 (1), 815-825, 2005.

Link

http://www.biken.osaka-u.ac.jp/