Department of Oncogene Research

Subjects:

1. Functional analyses of the Src family tyrosine kinases (SFK) in neural development.
2. Structural biology of SFK signaling.
3. Studies on SFK signaling in C. elegans.
4. Studies on SFK signaling in cancer cells.
5. Analyses of molecular mechanism of human cell transformation.
6. Functional analyses of the ASY gene.

Published Papers

1. The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function.

   Marc-Werner Dobenecker, Christian Schmedt, Masato Okada and Alexander Tarakhovsky

   Mol Cell Biol, 25 (23), 10533-10542, 2005.
2. SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.

   Bunsho Itoh, Takashi Hirose, Nozomu Takata, Kiyoji Nishiwaki, Makoto Koga, Yasumi Ohshima and Masato Okada

   Development, 132 (23), 5161-5172, 2005.
3. Role of Src family tyrosine kinases in the down-regulation of epidermal growth factor signaling in PC12 cells.

   Atsuko Kasai, Takaki Shima and Masato Okada

   Genes Cells, 10 (12), 1175-1187, 2005.
4. Potentiation of the ligand-binding activity of integrin alpha3beta1 via association with tetraspanin CD151.

   Ryoko Nishiuchi, Noriko Sanzen, Shigeyuki Nada, Yasuhiro Sumida, Yoshinao Wada, Masato Okada, Junichi Takagi, Hitoshi Hasegawa and Kiyotoshi Sekiguchi

   Proc Natl Acad Sci U S A, 102 (6), 1939-1944, 2005.
5. Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival.

   Ken-ichiro Kuwako, Akari Hosokawa, Isao Nishimura, Taichi Uetsuki, Masashi Yamada, Shigeyuki Nada, Masato Okada and Kazuaki Yoshikawa

   J Neurosci, 25 (30), 7090-7099, 2005.

Link

http://www.biken.osaka-u.ac.jp/