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Department of Cell Biology

DIVISION OF HOST DEFENSE:

Department of Cell Biology

Subjects:

  1. The role of heparin-binding EGF-like growth factor in development.
  2. The mode of actions of membrane-anchored growth factors.
  3. Ectodomain shedding mechanism of EGF family growth factor.
  4. Physiological role of CD9 and the tetraspanin family proteins.
  5. Epigenetics in germ cells: During germ cell differentiation, epigenetic information undergoes drastically changes. We are analyzing the molecular basis of the DNA methylation, histone modification and histone to protamine transition in spermatogenesis.
  6. Transcriptional regulation of germ cell specific genes: During male germ cell development, each differentiation step requires the expression of a specific set of precisely regulated genes. Some of these genes are exclusively expressed in male germ cells. We are characterizing the unique molecular mechanisms of the preinitiation complex formation for transcription in germ cells.

Published Papers

  1. Rina Kimura, Ryo Iwamoto and Eisuke Mekada
    Cell Struct Funct, 30 (2), 35-42, 2005.
  2. Naoki Mine, Ryo Iwamoto and Eisuke Mekada
    Development, 132 (19), 4317-4326, 2005.
  3. Yoshihiro Tanaka, Shingo Miyamoto, Satoshi O Suzuki, Eiji Oki, Hiroshi Yagi, Kenzo Sonoda, Ayano Yamazaki, Hiroto Mizushima, Yoshihiko Maehara, Eisuke Mekada and Hitoo Nakano
    Clin Cancer Res, 11 (13), 4783-4792, 2005.
  4. Pranee Somboonthum, Hiroshi Ohta, Shuichi Yamada, Masayoshi Onishi, Akiko Ike, Yoshitake Nishimune and Masami Nozaki
    Nucleic Acids Res, 33 (10), 3401-3411, 2005.
  5. Yuji Shirakata, Rina Kimura, Daisuke Nanba, Ryo Iwamoto, Sho Tokumaru, Chie Morimoto, Koichi Yokota, Masanori Nakamura, Koji Sayama, Eisuke Mekada, Shigeki Higashiyama and Koji Hashimoto
    J Cell Sci, 118 (Pt 11), 2363-2370, 2005.
  6. H Yagi, S Miyamoto, Y Tanaka, K Sonoda, H Kobayashi, T Kishikawa, R Iwamoto, E Mekada and H Nakano
    Br J Cancer, 92 (9), 1737-1745, 2005.
  7. Hideki Katayama, Haruo Yokota, Tetsuyuki Akao, Osamu Nakamura, Michio Ohba, Eisuke Mekada and Eiichi Mizuki
    J Biochem (Tokyo), 137 (1), 17-25, 2005.

Link

http://www.biken.osaka-u.ac.jp/

Last modified:2006/12/19 14:46:04
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References:[Table of Contents 2005]