Department of Bacterial Infections

Subjects:

1. Analysis of the bacterial colonization factors and their host receptors.
2. Molecular analysis of the protein toxins produced by various enteropathogens.
3. Analysis of the structure and function of the type III secretion system and the pathogenic mechanism of its effector.
4. Genome analysis of bacterial pathogens to understand pathogenic mechanisms.

Published Papers

1. Vibrios commonly possess two chromosomes.

   Kazuhisa Okada, Tetsuya Iida, Kumiko Kita-Tsukamoto and Takeshi Honda

   J Bacteriol, 187 (2), 752-757, 2005.
2. EspB from enterohaemorrhagic Escherichia coli is a natively partially folded protein.

   Daizo Hamada, Tomoaki Kato, Takahisa Ikegami, Kayo N Suzuki, Makoto Hayashi, Yoshikatsu Murooka, Takeshi Honda and Itaru Yanagihara

   FEBS J, 272 (3), 756-768, 2005.
3. Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system.

   Kunihiko Nishino, Takeshi Honda and Akihito Yamaguchi

   J Bacteriol, 187 (5), 1763-1772, 2005.
4. A pH-dependent conformational change in EspA, a component of the Escherichia coli O157:H7 type III secretion system.

   Tomoaki Kato, Daizo Hamada, Takashi Fukui, Makoto Hayashi, Takeshi Honda, Yoshikatsu Murooka and Itaru Yanagihara

   FEBS J, 272 (11), 2773-2783, 2005.
5. Thermostable direct hemolysin of Vibrio parahaemolyticus is a bacterial reversible amyloid toxin.

   Takashi Fukui, Kentaro Shiraki, Daizo Hamada, Kojiro Hara, Tomoko Miyata, Shinsuke Fujiwara, Kouta Mayanagi, Keiko Yanagihara, Tetsuya Iida, Eiichiro Fukusaki, Tadayuki Imanaka, Takeshi Honda and Itaru Yanagihara

   Biochemistry, 44 (29), 9825-9832, 2005.
6. Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus.

   Rabindra N Bhattacharjee, Kwon-Sam Park, Kazuhisa Okada, Yutaro Kumagai, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira, Tetsuya Iida and Takeshi Honda

   Biochem Biophys Res Commun, 335 (2), 328-334, 2005.
7. [Diagnostic tests: Bacterial protein toxins]

   Takeshi Honda

   Nippon Rinsho, 63 Suppl 7, 202-205, 2005.
8. vpaH, a gene encoding a novel histone-like nucleoid structure-like protein that was possibly horizontally acquired, regulates the biogenesis of lateral flagella in trh-positive Vibrio parahaemolyticus TH3996.

   Kwon-Sam Park, Michiko Arita, Tetsuya Iida and Takeshi Honda

   Infect Immun, 73 (9), 5754-5761, 2005.
9. [Providencia alcalifaciens as a newly recognized cause of food-borne disease]

   Takeshi Honda

   Shokuhin Eiseigaku Zasshi, 46 (4), J234-236, 2005.
10. Importance of Providencia species as a major cause of travellers' diarrhoea.

    Myonsun Yoh, Junko Matsuyama, Motoki Ohnishi, Kazuhiro Takagi, Hirozane Miyagi, Kazuhiro Mori, Kwon-Sam Park, Takahiro Ono and Takeshi Honda

    J Med Microbiol, 54 (Pt 11), 1077-1082, 2005.
11. Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest.

    Rabindra N Bhattacharjee, Kwon-Sam Park, Satoshi Uematsu, Kazuhisa Okada, Katsuaki Hoshino, Kiyoshi Takeda, Osamu Takeuchi, Shizuo Akira, Tetsuya Iida and Takeshi Honda

    FEBS Lett, 579 (29), 6604-6610, 2005.

Link

http://www.biken.osaka-u.ac.jp/