Department of Tumor Virology

Subjects:

1. Analysis on the spatio-temporal regulation of Ras-superfamily G protein.
2. Development of probes for the visualization of the growth signal transduction cascade.
3. Spatio-temporal analysis on the activity of small G proteins during neuronal morphogenesis.

Published Papers

1. Visualizing the signal transduction pathways in living cells with GFP-based FRET probes.

   Kazuo Kurokawa, Akiyuki Takaya, Kenta Terai, Aki Fujioka and Michiyuki Matsuda

   Acta Histochemica et Cytochemica, 37 (6), 347-355, 2004.
2. STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension.

   Chiemi Miyagi, Susumu Yamashita, Yusuke Ohba, Hisayoshi Yoshizaki, Michiyuki Matsuda and Toshio Hirano

   J Cell Biol, 166 (7), 975-981, 2004.
3. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.

   Taro Kawai, Shintaro Sato, Ken J Ishii, Cevayir Coban, Hiroaki Hemmi, Masahiro Yamamoto, Kenta Terai, Michiyuki Matsuda, Jun-ichiro Inoue, Satoshi Uematsu, Osamu Takeuchi and Shizuo Akira

   Nat Immunol, 5 (10), 1061-1068, 2004.
4. Cell type-specific regulation of RhoA activity during cytokinesis.

   Hisayoshi Yoshizaki, Yusuke Ohba, Maria-Carla Parrini, Natalya G Dulyaninova, Anne R Bresnick, Naoki Mochizuki and Michiyuki Matsuda

   J Biol Chem, 279 (43), 44756-44762, 2004.
5. Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion.

   Hajime Yano, Yuichi Mazaki, Kazuo Kurokawa, Steven K Hanks, Michiyuki Matsuda and Hisataka Sabe

   J Cell Biol, 166 (2), 283-295, 2004.
6. A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.

   Yuji Kamioka, Shigetomo Fukuhara, Hirofumi Sawa, Kazuo Nagashima, Michitaka Masuda, Michiyuki Matsuda and Naoki Mochizuki

   J Biol Chem, 279 (38), 40091-40099, 2004.
7. RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells.

   Akiyuki Takaya, Yusuke Ohba, Kazuo Kurokawa and Michiyuki Matsuda

   Mol Biol Cell, 15 (6), 2549-2557, 2004.
8. Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor.

   Kazuo Kurokawa, Reina E Itoh, Hisayoshi Yoshizaki, Yusuke Ohba Takeshi Nakamura and Michiyuki Matsuda

   Mol Biol Cell, 15 (3), 1003-1010, 2004.
9. Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells.

   Kazuhiro Aoki, Takeshi Nakamura and Michiyuki Matsuda

   J Biol Chem, 279 (1), 713-719, 2004.
10. A novel role of nectins in inhibition of the E-cadherin-induced activation of Rac and formation of cell-cell adherens junctions.

    Takashi Hoshino, Kazuya Shimizu, Tomoyuki Honda, Tomomi Kawakatsu, Taihei Fukuyama, Takeshi Nakamura, Michiyuki Matsuda and Yoshimi Takai

    Mol Biol Cell, 15 (3), 1077-1088, 2004.

Link

http://www.biken.osaka-u.ac.jp/