Department of Molecular Microbiology

Subjects:

1. Molecular mechanisms of recombination, repair, replication and mutagenesis.
2. Molecular mechanisms of signal transduction and regulation of gene expression.
3. Genome analysis of pathogenic bacteria and archaea.

Published Papers

1. Role of the Escherichia coli RecQ DNA helicase in SOS signaling and genome stabilization at stalled replication forks.

   Takashi Hishida, Yong-Woon Han, Tatsuya Shibata, Yoshino Kubota, Yoshizumi Ishino, Hiroshi Iwasaki and Hideo Shinagawa

   Genes Dev, 18 (15), 1886-1897, 2004.
2. Direct evidence that a conserved arginine in RuvB AAA+ ATPase acts as an allosteric effector for the ATPase activity of the adjacent subunit in a hexamer.

   Takashi Hishida, Yong-Woon Han, Satoko Fujimoto, Hiroshi Iwasaki and Hideo Shinagawa

   Proc Natl Acad Sci U S A, 101 (26), 9573-9577, 2004.
3. Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.

   Hirofumi Morikawa, Takashi Morishita, Shiho Kawane, Hiroshi Iwasaki, Antony M Carr and Hideo Shinagawa

   Mol Cell Biol, 24 (21), 9401-9413, 2004.
4. Cooperation of the N-terminal Helicase and C-terminal endonuclease activities of Archaeal Hef protein in processing stalled replication forks.

   Kayoko Komori, Masumi Hidaka, Takashi Horiuchi, Ryosuke Fujikane, Hideo Shinagawa and Yoshizumi Ishino

   J Biol Chem, 279 (51), 53175-53185, 2004.

Link

http://www.biken.osaka-u.ac.jp/