Department of Molecular Genetics

Subjects:

1. Molecular mechanisms regulating the G1/ G0 or G1/S transition and the cell cycle checkpoints in yeast and mammalian cells.
2. Molecular mechanisms controlling the cell cycle and meiosis in budding and fission yeasts.
3. Molecular mechanisms modulating the metastasis of malignant cells.
4. Development and application of new techniques for the stepwise subtraction of cDNA libraries.

Published Papers

1. G1 and S-phase checkpoints, chromosome instability, and cancer.

   Hiroshi Nojima

   Methods Mol Biol, 280, 3-49, 2004.
2. The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

   Shingo Toji, Norikazu Yabuta, Toshiya Hosomi, Souichi Nishihara, Toshiko Kobayashi, Susumu Suzuki, Katsuyuki Tamai and Hiroshi Nojima

   Genes Cells, 9 (5), 383-397, 2004.
3. A derivative of oleamide potently inhibits the spontaneous metastasis of mouse melanoma BL6 cells.

   Akihiko Ito, Nobuyoshi Morita, Daisaku Miura, Yu-Ichiro Koma, Tatsuki R Kataoka, Hiroshi Yamasaki, Yukihiko Kitamura, Yasuyuki Kita and Hiroshi Nojima

   Carcinogenesis, 25 (10), 2015-2022, 2004.
4. Mcp7, a meiosis-specific coiled-coil protein of fission yeast, associates with Meu13 and is required for meiotic recombination.

   Takamune T Saito, Takahiro Tougan, Takashi Kasama, Daisuke Okuzaki and Hiroshi Nojima

   Nucleic Acids Res, 32 (11), 3325-3339, 2004.

Link

http://www.biken.osaka-u.ac.jp/