Department of Host Defense

Subjects:

1. Physiological roles of Toll-like receptor (TLR) family and signaling pathways via TLRs.
2. Pathogen recognition mechanisms by innate immune system.

Published Papers

1. Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.

   Anne Krug, Gary D Luker, Winfried Barchet, David A Leib, Shizuo Akira and Marco Colonna

   Blood, 103 (4), 1433-1437, 2004.
2. Adjuvant-mediated tumor regression and tumor-specific cytotoxic response are impaired in MyD88-deficient mice.

   Takashi Akazawa, Hisayo Masuda, Yoshiko Saeki, Misako Matsumoto, Kiyoshi Takeda, Kunio Tsujimura, Kiyotaka Kuzushima, Toshitada Takahashi, Ichiro Azuma, Shizuo Akira, Kumao Toyoshima and Tsukasa Seya

   Cancer Res, 64 (2), 757-764, 2004.
3. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88.

   Marco A Campos, Meire Closel, Eneida P Valente, Jarbas E Cardoso, Shizuo Akira, Jacqueline I Alvarez-Leite, Catherine Ropert and Ricardo T Gazzinelli

   J Immunol, 172 (3), 1711-1718, 2004.
4. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.

   Hiroshi Inoue, Wataru Ogawa, Michitaka Ozaki, Sanae Haga, Michihiro Matsumoto, Kensuke Furukawa, Naoko Hashimoto, Yoshiaki Kido, Toshiyuki Mori, Hiroshi Sakaue, Kiyoshi Teshigawara, Shiyu Jin, Haruhisa Iguchi, Ryuji Hiramatsu, Derek LeRoith, Kiyoshi Takeda, Shizuo Akira and Masato Kasuga

   Nat Med, 10 (2), 168-174, 2004.
5. Gamma interferon (IFN-gamma) and IFN-gamma-inducing cytokines interleukin-12 (IL-12) and IL-18 do not augment infection-stimulated bone resorption in vivo.

   Hajime Sasaki, Khaled Balto, Nobuyuki Kawashima, Jean Eastcott, Katsuaki Hoshino, Shizuo Akira and Philip Stashenko

   Clin Diagn Lab Immunol, 11 (1), 106-110, 2004.
6. Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation.

   Takeshi Into, Kazuto Kiura, Motoaki Yasuda, Hideo Kataoka, Nobuo Inoue, Akira Hasebe, Kiyoshi Takeda, Shizuo Akira and Ken-ichiro Shibata

   Cell Microbiol, 6 (2), 187-199, 2004.
7. Stat-3 is required for pulmonary homeostasis during hyperoxia.

   Isamu Hokuto, Machiko Ikegami, Mitsuhiro Yoshida, Kiyoshi Takeda, Shizuo Akira, Anne-Karina T Perl, William M Hull, Susan E Wert and Jeffrey A Whitsett

   J Clin Invest, 113 (1), 28-37, 2004.
8. Contribution of Toll-like receptor 9 signaling to the acute inflammatory response to nonviral vectors.

   Hongmei Zhao, Hiraoki Hemmi, Shizuo Akira, Seng H Cheng, Ronald K Scheule and Nelson S Yew

   Mol Ther, 9 (2), 241-248, 2004.
9. TLR signaling pathways.

   Kiyoshi Takeda and Shizuo Akira

   Semin Immunol, 16 (1), 3-9, 2004.
10. Toll receptor families: structure and function.

    S Akira

    Semin Immunol, 16 (1), 1-2, 2004.
11. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration.

    Mathias Heikenwalder, Magdalini Polymenidou, Tobias Junt, Christina Sigurdson, Hermann Wagner, Shizuo Akira, Rolf Zinkernagel and Adriano Aguzzi

    Nat Med, 10 (2), 187-192, 2004.
12. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.

    Daniel Rachmilewitz, Kyoko Katakura, Fanny Karmeli, Tomoko Hayashi, Constantin Reinus, Bernard Rudensky, Shizuo Akira, Kiyoshi Takeda, Jongdae Lee, Kenji Takabayashi and Eyal Raz

    Gastroenterology, 126 (2), 520-528, 2004.
13. Inhibitory effect of Toll-like receptor 4 on fusion between phagosomes and endosomes/lysosomes in macrophages.

    Akiko Shiratsuchi, Ikuko Watanabe, Osamu Takeuchi, Shizuo Akira and Yoshinobu Nakanishi

    J Immunol, 172 (4), 2039-2047, 2004.
14. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.

    Sandra S Diebold, Tsuneyasu Kaisho, Hiroaki Hemmi, Shizuo Akira and Caetano Reis e Sousa

    Science, 303 (5663), 1529-1531, 2004.
15. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.

    Florian Heil, Hiroaki Hemmi, Hubertus Hochrein, Franziska Ampenberger, Carsten Kirschning, Shizuo Akira, Grayson Lipford, Hermann Wagner and Stefan Bauer

    Science, 303 (5663), 1526-1529, 2004.
16. Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense.

    Sylvia Knapp, Catharina W Wieland, Cornelis van 't Veer, Osamu Takeuchi, Shizuo Akira, Sandrine Florquin and Tom van der Poll

    J Immunol, 172 (5), 3132-3138, 2004.
17. IL-18 gene therapy develops Th1-type immune responses in Leishmania major-infected BALB/c mice: is the effect mediated by the CpG signaling TLR9?

    Y Li, K Ishii, H Hisaeda, S Hamano, M Zhang, K Nakanishi, T Yoshimoto, H Hemmi, K Takeda, S Akira, Y Iwakura and K Himeno

    Gene Ther, 11 (11), 941-948, 2004.
18. Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype.

    Paul M Robben, Dana G Mordue, Steven M Truscott, Kiyoshi Takeda, Shizuo Akira and L David Sibley

    J Immunol, 172 (6), 3686-3694, 2004.
19. Lipopolysaccharide from Coxiella burnetii is involved in bacterial phagocytosis, filamentous actin reorganization, and inflammatory responses through Toll-like receptor 4.

    Amélie Honstettre, Eric Ghigo, Alix Moynault, Christian Capo, Rudolf Toman, Shizuo Akira, Osamu Takeuchi, Hubert Lepidi, Didier Raoult and Jean-Louis Mege

    J Immunol, 172 (6), 3695-3703, 2004.
20. Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy.

    Kazunori Yukawa, Katsuaki Hoshino, Masanori Kishino, Masatoshi Mune, Nobuyuki Shirasawa, Akihiko Kimura, Yuji Tsubota, Kyoko Owada-Makabe, Tetsuji Tanaka, Masakazu Ichinose, Masanobu Maeda, Kiyoshi Takeda and Shizuo Akira

    Int J Mol Med, 13 (4), 515-520, 2004.
21. Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium.

    M Salomé Gomes, Manuela Flórido, João V Cordeiro, C Miguel Teixeira, Osamu Takeuchi, Shizuo Akira and Rui Appelberg

    Immunology, 111 (2), 179-185, 2004.
22. Microbial recognition by Toll-like receptors.

    Kiyoshi Takeda and Shizuo Akira

    J Dermatol Sci, 34 (2), 73-82, 2004.
23. Toll-like receptors are temporally involved in host defense.

    David S Weiss, Bärbel Raupach, Kiyoshi Takeda, Shizuo Akira and Arturo Zychlinsky

    J Immunol, 172 (7), 4463-4469, 2004.
24. Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection.

    David Torres, Mathieu Barrier, Franck Bihl, Valerie J F Quesniaux, Isabelle Maillet, Shizuo Akira, Bernhard Ryffel and François Erard

    Infect Immun, 72 (4), 2131-2139, 2004.
25. Expression of Toll-like receptors 2 and 4 is downregulated after operation.

    Hirofumi Ikushima, Toshirou Nishida, Kiyoshi Takeda, Toshinori Ito, Takushi Yasuda, Masahiko Yano, Shizuo Akira and Hikaru Matsuda

    Surgery, 135 (4), 376-385, 2004.
26. Interferon-gamma production and host protective response against Mycobacterium tuberculosis in mice lacking both IL-12p40 and IL-18.

    Kazuyoshi Kawakami, Yuki Kinjo, Kaori Uezu, Kazuya Miyagi, Takeshi Kinjo, Satomi Yara, Yoshinobu Koguchi, Akiko Miyazato, Kazutoshi Shibuya, Yoichiro Iwakura, Kiyoshi Takeda, Shizuo Akira and Atsushi Saito

    Microbes Infect, 6 (4), 339-349, 2004.
27. A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells.

    Stephanie Dillon, Anshu Agrawal, Thomas Van Dyke, Gary Landreth, Laurie McCauley, Amy Koh, Charles Maliszewski, Shizuo Akira and Bali Pulendran

    J Immunol, 172 (8), 4733-4743, 2004.
28. Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway.

    Sathit Pichyangkul, Kosol Yongvanitchit, Utaiwan Kum-arb, Hiroaki Hemmi, Shizuo Akira, Arthur M Krieg, D Gray Heppner, V Ann Stewart, Hitoshi Hasegawa, Sornchai Looareesuwan, G Dennis Shanks and R Scott Miller

    J Immunol, 172 (8), 4926-4933, 2004.
29. Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse.

    Keisuke Takeshita, Tsugiko Yamasaki, Shizuo Akira, Florian Gantner and Kevin B Bacon

    Int Immunol, 16 (5), 685-695, 2004.
30. Abnormal retinal vascular development in IL-18 knockout mice.

    Hong Qiao, Koh-Hei Sonoda, Yukio Sassa, Toshio Hisatomi, Hiroshi Yoshikawa, Yasuhiro Ikeda, Toshinori Murata, Shizuo Akira and Tatsuro Ishibashi

    Lab Invest, 84 (8), 973-980, 2004.
31. Glucocorticoids synergize with IL-1beta to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells.

    Akihiro Sakai, Jiahuai Han, Andrew C B Cato, Shizuo Akira and Jian-Dong Li

    BMC Mol Biol, 5 (1), 2, 2004.
32. Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease.

    Giuseppe Mancuso, Angelina Midiri, Concetta Beninati, Carmelo Biondo, Roberta Galbo, Shizuo Akira, Philipp Henneke, Douglas Golenbock and Giuseppe Teti

    J Immunol, 172 (10), 6324-6329, 2004.
33. Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells.

    Toru Hosoi, Sawako Suzuki, Jun Nomura, Atsushi Ono, Yasunobu Okuma, Shizuo Akira and Yasuyuki Nomura

    Brain Res Mol Brain Res, 124 (2), 159-164, 2004.
34. Toll-like receptor 4 mediates the antitumor host response induced by a 55-kilodalton protein isolated from Aeginetia indica L., a parasitic plant.

    Masato Okamoto, Go Oh-E, Tetsuya Oshikawa, Sachiko Furuichi, Tomoyuki Tano, Sharif U Ahmed, Sachiko Akashi, Kensuke Miyake, Osamu Takeuchi, Shizuo Akira, Kunisuke Himeno, Mitsunobu Sato and Shinya Ohkubo

    Clin Diagn Lab Immunol, 11 (3), 483-495, 2004.
35. Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1.

    Daisuke Kamei, Kiyofumi Yamakawa, Yui Takegoshi, Maya Mikami-Nakanishi, Yoshihito Nakatani, Sachiko Oh-Ishi, Hidekazu Yasui, Yoshiaki Azuma, Noriyasu Hirasawa, Kazuo Ohuchi, Hiroshi Kawaguchi, Yukio Ishikawa, Toshiharu Ishii, Satoshi Uematsu, Shizuo Akira, Makoto Murakami and Ichiro Kudo

    J Biol Chem, 279 (32), 33684-33695, 2004.
36. Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF.

    Chunsun Dai and Youhua Liu

    J Am Soc Nephrol, 15 (6), 1402-1412, 2004.
37. High occurrence of simultaneous mutations in target enzymes and MtrRCDE efflux system in quinolone-resistant Neisseria gonorrhoeae.

    Beti Ernawati Dewi, Sasaki Akira, Hideo Hayashi and William Ba-Thein

    Sex Transm Dis, 31 (6), 353-359, 2004.
38. Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88.

    Nadra Nilsen, Unni Nonstad, Naseema Khan, Cathrine F Knetter, Shizuo Akira, Anders Sundan, Terje Espevik and Egil Lien

    J Biol Chem, 279 (38), 39727-39735, 2004.
39. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.

    Shin-Ichi Gorogawa, Yoshio Fujitani, Hideaki Kaneto, Yoji Hazama, Hirotaka Watada, Yasuhide Miyamoto, Kiyoshi Takeda, Shizuo Akira, Mark A Magnuson, Yoshimitsu Yamasaki, Yoshitaka Kajimoto and Masatsugu Hori

    Biochem Biophys Res Commun, 319 (4), 1159-1170, 2004.
40. Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain.

    Tamaki Mabuchi, Hiroyuki Kojima, Tetsuya Abe, Kunio Takagi, Madoka Sakurai, Yoshihiro Ohmiya, Satoshi Uematsu, Shizuo Akira, Kikuko Watanabe and Seiji Ito

    Neuroreport, 15 (9), 1395-1398, 2004.
41. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.

    Melissa W Boulé, Courtney Broughton, Fabienne Mackay, Shizuo Akira, Ann Marshak-Rothstein and Ian R Rifkin

    J Exp Med, 199 (12), 1631-1640, 2004.
42. Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina.

    Yoko Ozawa, Keiko Nakao, Takuya Shimazaki, Junji Takeda, Shizuo Akira, Katsuhiko Ishihara, Toshio Hirano, Yoshihisa Oguchi and Hideyuki Okano

    Mol Cell Neurosci, 26 (2), 258-270, 2004.
43. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.

    Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa, Noriaki Shinobu, Tadaatsu Imaizumi, Makoto Miyagishi, Kazunari Taira, Shizuo Akira and Takashi Fujita

    Nat Immunol, 5 (7), 730-737, 2004.
44. The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.

    Hiroaki Hemmi, Osamu Takeuchi, Shintaro Sato, Masahiro Yamamoto, Tsuneyasu Kaisho, Hideki Sanjo, Taro Kawai, Katsuaki Hoshino, Kiyoshi Takeda and Shizuo Akira

    J Exp Med, 199 (12), 1641-1650, 2004.
45. Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury.

    Masanori Kishino, Kazunori Yukawa, Katsuaki Hoshino, Akihiko Kimura, Nobuyuki Shirasawa, Haruhisa Otani, Tetsuji Tanaka, Kyoko Owada-Makabe, Yuji Tsubota, Masanobu Maeda, Masakazu Ichinose, Kiyoshi Takeda, Shizuo Akira and Masatoshi Mune

    J Am Soc Nephrol, 15 (7), 1826-1834, 2004.
46. Toll-like receptor signalling.

    Shizuo Akira and Kiyoshi Takeda

    Nat Rev Immunol, 4 (7), 499-511, 2004.
47. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.

    Masahiro Yamamoto, Soh Yamazaki, Satoshi Uematsu, Shintaro Sato, Hiroaki Hemmi, Katsuaki Hoshino, Tsuneyasu Kaisho, Hirotaka Kuwata, Osamu Takeuchi, Koichiro Takeshige, Tatsuya Saitoh, Shoji Yamaoka, Naoki Yamamoto, Shunsuke Yamamoto, Tatsushi Muta, Kiyoshi Takeda and Shizuo Akira

    Nature, 430 (6996), 218-222, 2004.
48. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.

    Kathrin S Michelsen, Michelle H Wong, Prediman K Shah, Wenxuan Zhang, Juliana Yano, Terence M Doherty, Shizuo Akira, Tripathi B Rajavashisth and Moshe Arditi

    Proc Natl Acad Sci U S A, 101 (29), 10679-10684, 2004.
49. Chronic pneumonia despite adaptive immune response to Mycobacterium bovis BCG in MyD88-deficient mice.

    Delphine M Nicolle, Xavier Pichon, André Bouchot, Isabelle Maillet, François Erard, Shizuo Akira, Bernhard Ryffel and Valérie F J Quesniaux

    Lab Invest, 84 (10), 1305-1321, 2004.
50. MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.

    Devin D Bolz, Rhianna S Sundsbak, Ying Ma, Shizuo Akira, Carsten J Kirschning, James F Zachary, John H Weis and Janis J Weis

    J Immunol, 173 (3), 2003-2010, 2004.
51. Expression of toll-like receptor 4 on dendritic cells is significant for anticancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432, a streptococcal preparation.

    Masato Okamoto, Sachiko Furuichi, Yasuhiko Nishioka, Tetsuya Oshikawa, Tomoyuki Tano, Sharif Uddin Ahmed, Kiyoshi Takeda, Shizuo Akira, Yoshiki Ryoma, Yoichiro Moriya, Motoo Saito, Saburo Sone and Mitsunobu Sato

    Cancer Res, 64 (15), 5461-5470, 2004.
52. Human papillomavirus type-16 virus-like particles activate complementary defense responses in key dendritic cell subpopulations.

    Rongcun Yang, Francisco Martinez Murillo, Ken-Yu Lin, William H Yutzy, Satoshi Uematsu, Kiyoshi Takeda, Shizuo Akira, Raphael P Viscidi and Richard B S Roden

    J Immunol, 173 (4), 2624-2631, 2004.
53. Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning.

    Robert M Smith, Naushaad Suleman, Lydia Lacerda, Lionel H Opie, Shizuo Akira, Kenneth R Chien and Michael N Sack

    Cardiovasc Res, 63 (4), 611-616, 2004.
54. In vivo transfection of a cis element 'decoy' against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model.

    H Yokozeki, M-H Wu, K Sumi, S Awad, T Satoh, I Katayama, K Takeda, S Akira, Y Kaneda and K Nishioka

    Gene Ther, 11 (24), 1753-1762, 2004.
55. In vivo transfection of a cis element 'decoy' against signal transducers and activators of the transcription 6 (STAT6) binding site ameliorates the response of contact hypersensitivity.

    K Sumi, H Yokozeki, M-H Wu, T Satoh, Y Kaneda, K Takeda, S Akira and K Nishioka

    Gene Ther, 11 (24), 1763-1771, 2004.
56. IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition.

    Sihyug Jang, Satoshi Uematsu, Shizuo Akira and Padmini Salgame

    J Immunol, 173 (5), 3392-3397, 2004.
57. The role of IFN-gamma and Toll-like receptors in nephropathy induced by Toxoplasma gondii infection.

    Masamichi Kudo, Fumie Aosai, Hye-Seong Mun, Kazumi Norose, Shizuo Akira, Yoichiro Iwakura and Akihiko Yano

    Microbiol Immunol, 48 (8), 617-628, 2004.
58. Functions of toll-like receptors: lessons from KO mice.

    Shizuo Akira and Kiyoshi Takeda

    C R Biol, 327 (6), 581-589, 2004.
59. CCAAT/Enhancer-binding protein delta contributes to myofibroblast transdifferentiation and renal disease progression.

    Masanobu Takeji, Noritaka Kawada, Toshiki Moriyama, Katsuyuki Nagatoya, Susumu Oseto, Shizuo Akira, Masatsugu Hori, Enyu Imai and Takeshi Miwa

    J Am Soc Nephrol, 15 (9), 2383-2390, 2004.
60. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function.

    Anne Krug, Anthony R French, Winfried Barchet, Jens A A Fischer, Andrzej Dzionek, Jeanette T Pingel, Michael M Orihuela, Shizuo Akira, Wayne M Yokoyama and Marco Colonna

    Immunity, 21 (1), 107-119, 2004.
61. MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha.

    Nobuaki Sato, Naoyuki Takahashi, Koji Suda, Midori Nakamura, Mariko Yamaki, Tadashi Ninomiya, Yasuhiro Kobayashi, Haruhiko Takada, Kenichiro Shibata, Masahiro Yamamoto, Kiyoshi Takeda, Shizuo Akira, Toshihide Noguchi and Nobuyuki Udagawa

    J Exp Med, 200 (5), 601-611, 2004.
62. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.

    Taro Kawai, Shintaro Sato, Ken J Ishii, Cevayir Coban, Hiroaki Hemmi, Masahiro Yamamoto, Kenta Terai, Michiyuki Matsuda, Jun-ichiro Inoue, Satoshi Uematsu, Osamu Takeuchi and Shizuo Akira

    Nat Immunol, 5 (10), 1061-1068, 2004.
63. Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.

    Benjamin R tenOever, Sonia Sharma, Wen Zou, Qiang Sun, Nathalie Grandvaux, Ilkka Julkunen, Hiroaki Hemmi, M Yamamoto, Shizuo Akira, Wen-Chen Yeh, Rongtuan Lin and John Hiscott

    J Virol, 78 (19), 10636-10649, 2004.
64. Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control.

    Anna Vossenkämper, Daniela Struck, Cosme Alvarado-Esquivel, Tobias Went, Kioyshi Takeda, Shizuo Akira, Klaus Pfeffer, Gottfried Alber, Matthias Lochner, Irmgard Förster and Oliver Liesenfeld

    Eur J Immunol, 34 (11), 3197-3207, 2004.
65. Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells.

    Ann Marshak-Rothstein, Liliana Busconi, Christina M Lau, Abigail S Tabor, Elizabeth A Leadbetter, Shizuo Akira, Arthur M Krieg, Grayson B Lipford, Gregory A Viglianti and Ian R Rifkin

    J Endotoxin Res, 10 (4), 247-251, 2004.
66. Interferon response induced by Toll-like receptor signaling.

    Osamu Takeuchi, Hiroaki Hemmi and Shizuo Akira

    J Endotoxin Res, 10 (4), 252-256, 2004.
67. Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice.

    Chikara Nakasone, Kazuyoshi Kawakami, Tomoaki Hoshino, Yusuke Kawase, Koichi Yokota, Kohichiro Yoshino, Kiyoshi Takeda, Shizuo Akira and Atsushi Saito

    Infect Immun, 72 (10), 6176-6180, 2004.
68. A patient with back pain and unusual appearances on bone scintigraphy.

    S Chilab, E Macias and N W Garvie

    Br J Radiol, 77 (921), 801-802, 2004.
69. Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88.

    Rongcun Yang, Francisco Martinez Murillo, Hengmi Cui, Richard Blosser, Satoshi Uematsu, Kiyoshi Takeda, Shizuo Akira, Raphael P Viscidi and Richard B S Roden

    J Virol, 78 (20), 11152-11160, 2004.
70. Toll-like Receptors and Sepsis.

    Ken Ishii and Shizuo Akira

    Curr Infect Dis Rep, 6 (5), 361-366, 2004.
71. Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha.

    Michelle L Chaisson, Daniel G Branstetter, Jonathan M Derry, Allison P Armstrong, Mark E Tometsko, Kiyoshi Takeda, Shizuo Akira and William C Dougall

    J Biol Chem, 279 (52), 54841-54848, 2004.
72. Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice.

    Shungo Hikoso, Osamu Yamaguchi, Yoshiharu Higuchi, Shinichi Hirotani, Toshihiro Takeda, Kazunori Kashiwase, Tetsuya Watanabe, Masayuki Taniike, Ikuko Tsujimoto, Michio Asahi, Yasushi Matsumura, Kazuhiko Nishida, Hiroshi Nakajima, Shizuo Akira, Masatsugu Hori and Kinya Otsu

    Circulation, 110 (17), 2631-2637, 2004.
73. Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.

    Ana-Carolina Oliveira, Jaqueline R Peixoto, Luciana B de Arruda, Marco A Campos, Ricardo T Gazzinelli, Douglas T Golenbock, Shizuo Akira, José O Previato, Lúcia Mendonça-Previato, Alberto Nobrega and Maria Bellio

    J Immunol, 173 (9), 5688-5696, 2004.
74. ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules.

    Masatatsu Yamamoto, Katsuyuki Yaginuma, Hiroko Tsutsui, Junji Sagara, Xin Guan, Ekihiro Seki, Koubun Yasuda, Masahiro Yamamoto, Shizuo Akira, Kenji Nakanishi, Tetsuo Noda and Shun'ichiro Taniguchi

    Genes Cells, 9 (11), 1055-1067, 2004.
75. Bacterial endotoxin induces IL-20 expression in the glial cells.

    Toru Hosoi, Sachiyo Wada, Sawako Suzuki, Yasunobu Okuma, Shizuo Akira, Tadashi Matsuda and Yasuyuki Nomura

    Brain Res Mol Brain Res, 130 (1-2), 23-29, 2004.
76. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.

    Trude H Flo, Kelly D Smith, Shintaro Sato, David J Rodriguez, Margaret A Holmes, Roland K Strong, Shizuo Akira and Alan Aderem

    Nature, 432 (7019), 917-921, 2004.
77. Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart.

    Pascal Knuefermann, Yasushi Sakata, J Scott Baker, Chien-Hua Huang, Kenichi Sekiguchi, Hordur S Hardarson, Osamu Takeuchi, Shizuo Akira and Jesus G Vallejo

    Circulation, 110 (24), 3693-3698, 2004.
78. Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity.

    Yoshinori Suzuki, Daiko Wakita, Kenji Chamoto, Yoshinori Narita, Takemasa Tsuji, Tsuguhide Takeshima, Hiroshi Gyobu, You Kawarada, Satoshi Kondo, Shizuo Akira, Hiroyuki Katoh, Hiroaki Ikeda and Takashi Nishimura

    Cancer Res, 64 (23), 8754-8760, 2004.
79. IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.

    Silvia Stockinger, Benjamin Reutterer, Barbara Schaljo, Carola Schellack, Sylvia Brunner, Tilo Materna, Masahiro Yamamoto, Shizuo Akira, Tadatsugu Taniguchi, Peter J Murray, Mathias Müller and Thomas Decker

    J Immunol, 173 (12), 7416-7425, 2004.
80. Pleiotropic function of Toll-like receptors.

    Tsuneyasu Kaisho and Shizuo Akira

    Microbes Infect, 6 (15), 1388-1394, 2004.

Link

http://www.biken.osaka-u.ac.jp/