Department of Bacterial Toxinology

Subjects:

1. Search for novel virulence factors produced by pathogenic bacteria.
2. Analysis of structure and function of bacterial virulence factors.

Published Papers

1. Bordetella dermonecrotic toxin undergoes proteolytic processing to be translocated from a dynamin-related endosome into the cytoplasm in an acidification-independent manner.

   Takeshi Matsuzawa, Aya Fukui, Takashige Kashimoto, Kaori Nagao, Kiyomasa Oka, Masami Miyake and Yasuhiko Horiguchi

   J Biol Chem, 279 (4), 2866-2872, 2004.
2. Bordetella dermonecrotic toxin exerting toxicity through activation of the small GTPase Rho.

   Aya Fukui and Yasuhiko Horiguchi

   J Biochem (Tokyo), 136 (4), 415-419, 2004.

Link

http://www.biken.osaka-u.ac.jp/