Department of Tumor Virology

Subjects:

1. Analysis on the spatio-temporal regulation of Ras-superfamily G protein.
2. Development of probes for the visualization of the growth signal transduction cascade.
3. Spatio-temporal analysis on the activity of small G proteins during neuronal morphogenesis.

Papers published in 2003

1. Mechanism of the spatio-temporal regulation of Ras and Rap1.

   Yusuke Ohba, Kazuo Kurokawa and Michiyuki Matsuda

   EMBO J, 22 (4), 859-869, 2003.
2. Cdc42 and Rac small G proteins activated by trans-interactions of nectins are involved in activation of c-Jun N-terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts.

   Tomoyuki Honda, Kazuya Shimizu, Tomomi Kawakatsu, Atsunori Fukuhara, Kenji Irie, Takeshi Nakamura, Michiyuki Matsuda and Yoshimi Takai

   Genes Cells, 8 (5), 481-491, 2003.
3. Activity of Rho-family GTPases during cell division as visualized with FRET-based probes.

   Hisayoshi Yoshizaki, Yusuke Ohba, Kazuo Kurokawa, Reina E Itoh, Takeshi Nakamura, Naoki Mochizuki, Kazuo Nagashima and Michiyuki Matsuda

   J Cell Biol, 162 (2), 223-232, 2003.

Link

http://www.biken.osaka-u.ac.jp/