Department of Oncogene Research

Subjects:

1. Functional analyses of the Src family tyrosine kinases (SFK) in neural development.
2. Structural biology of SFK signaling.
3. Studies on SFK signaling in C. elegans.
4. Studies on SFK signaling in cancer cells.
5. Analyses of molecular mechanism of human cell transformation.
6. Functional analyses of the ASY gene.

Papers published in 2003

1. Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase.

   Ryouhei Tsutsumi, Hideaki Higashi, Megumi Higuchi, Masato Okada and Masanori Hatakeyama

   J Biol Chem, 278 (6), 3664-3670, 2003.
2. Multi-functional gene ASY/Nogo/RTN-X/RTN4: apoptosis, tumor suppression, and inhibition of neuronal regeneration.

   A Watari and M Yutsudo

   Apoptosis, 8 (1), 5-9, 2003.
3. Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans.

   Takashi Hirose, Makoto Koga, Yasumi Ohshima and Masato Okada

   FEBS Lett, 534 (1-3), 133-138, 2003.
4. Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway.

   Kimiko Shimizu, Masato Okada, Katsuya Nagai and Yoshitaka Fukada

   J Biol Chem, 278 (17), 14920-14925, 2003.
5. Csk regulates integrin-mediated signals: involvement of differential activation of ERK and Akt.

   Jianguo Gu, Shigeyuki Nada, Masato Okada and Kiyotoshi Sekiguchi

   Biochem Biophys Res Commun, 303 (3), 973-977, 2003.
6. Identification of the human IAI.3B promoter element and its use in the construction of a replication-selective adenovirus for ovarian cancer therapy.

   Katsuyuki Hamada, Shohei Kohno, Mari Iwamoto, Hiroko Yokota, Masato Okada, Masatoshi Tagawa, Susumu Hirose, Kenshi Yamasaki, Yuji Shirakata, Koji Hashimoto and Masaharu Ito

   Cancer Res, 63 (10), 2506-2512, 2003.
7. Pro-apoptotic ASY/Nogo-B protein associates with ASYIP.

   Bing Qi, Yipeng Qi, Akihiro Watari, Naohisa Yoshioka, Hirokazu Inoue, Yuzuru Minemoto, Katsumi Yamashita, Toshiyuki Sasagawa and Masuo Yutsudo

   J Cell Physiol, 196 (2), 312-318, 2003.
8. Changes in L1 and NCAM expression in the rat suprachiasmatic nucleus during growth and after orbital enucleation.

   Shigeru Yamada, Yoshiharu Takayama, Tatsunori Seki, Masato Okada and Katsuya Nagai

   Brain Res Dev Brain Res, 143 (2), 189-198, 2003.
9. Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn.

   Shigeyuki Nada, Takaki Shima, Hiroyuki Yanai, Holger Husi, Seth G N Grant, Masato Okada and Tetsu Akiyama

   J Biol Chem, 278 (48), 47610-47621, 2003.
10. Transmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts.

    Takaki Shima, Shigeyuki Nada and Masato Okada

    Proc Natl Acad Sci U S A, 100 (25), 14897-14902, 2003.
11. Expression of Epstein-Barr virus in thyroid carcinoma correlates with tumor progression.

    Misuzu Shimakage, Kunimitsu Kawahara, Toshiyuki Sasagawa, Hirokazu Inoue, Masuo Yutsudo, Akira Yoshida and Syunsuke Yanoma

    Hum Pathol, 34 (11), 1170-1177, 2003.

Link

http://www.biken.osaka-u.ac.jp/