Department of Molecular Protozoology

Subjects:

1. Development of a malaria vaccine.
2. Development of anti-malarials based on computer drug design.5.
3. Study on host-parasite interaction of malaria infection.
4. Molecular mechanism underlying the intraerythrocytic proliferation of Plasmodium falciparum.

Papers published in 2003

1. [Can genome sequences save tropical countries?: outcome form the genome sequences of malaria parasite, Plasmodium falciparum and malaria mosquito, Anopheles gambiae]

   Dan Sato and Toshihiro Horii

   Tanpakushitsu Kakusan Koso, 48 (2), 149-155, 2003.
2. Regulation of RecA protein binding to DNA by opposing effects of ATP and ADP on inter-domain contacts: analysis by urea-induced unfolding of wild-type and C-terminal truncated RecA.

   Jun Yamazaki, Toshihiro Horii, Mutsuo Sekiguchi and Masayuki Takahashi

   J Mol Biol, 329 (2), 363-370, 2003.
3. Lipid metabolism in Plasmodium falciparum-infected erythrocytes: possible new targets for malaria chemotherapy.

   Toshihide Mitamura and Nirianne Marie Q Palacpac

   Microbes Infect, 5 (6), 545-552, 2003.
4. Sequence diversity in the amino-terminal region of the malaria-vaccine candidate serine repeat antigen in natural Plasmodium falciparum populations.

   Indri Safitri, Amadu Jalloh, Indah S Tantular, Suhintam Pusarawati, Thin Thida Win, Qing Liu, Marcelo U Ferreira, Yoes P Dachlan, Toshihiro Horii and Fumihiko Kawamoto

   Parasitol Int, 52 (2), 117-131, 2003.
5. New anti-malarial peroxides with in vivo potency derived from spongean metabolites.

   Nobutoshi Murakami, Motoyuki Kawanishi, Huq Mohammad Mostaqul, Jie Li, Sawako Itagaki, Toshihiro Horii and Motomasa Kobayashi

   Bioorg Med Chem Lett, 13 (22), 4081-4084, 2003.

Link

http://www.biken.osaka-u.ac.jp/