Department of Molecular Immunology

Subjects:

1. Mechanism of regulation of humoral and cellular immune responses.
2. Mechanism of development of autoimmune diseases.
3. Analysis of signaling mechanisms of cytokines and costimulatory molecules.

Papers published in 2003

1. Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.

   Thomas Stratmann, Natalia Martin-Orozco, Valérie Mallet-Designe, Laurent Poirot, Dorian McGavern, Grigoriy Losyev, Cathleen M Dobbs, Michael B A Oldstone, Kenji Yoshida, Hitoshi Kikutani, Diane Mathis, Christophe Benoist, Kathryn Haskins and Luc Teyton

   J Clin Invest, 112 (6), 902-914, 2003.
2. CD100/Sema4D, a lymphocyte semaphorin involved in the regulation of humoral and cellular immune responses.

   Kazuhiro Suzuki, Atsushi Kumanogoh and Hitoshi Kikutani

   Cytokine Growth Factor Rev, 14 (1), 17-24, 2003.
3. Semaphorins in interactions between T cells and antigen-presenting cells.

   Hitoshi Kikutani and Atsushi Kumanogoh

   Nat Rev Immunol, 3 (2), 159-167, 2003.
4. Increased susceptibility to airway responses in CD40-deficient mice.

   H Takahashi, S Ebihara, A Kanda, M Kamanaka, T Sato, S Habu, H Kikutani and H Sasaki

   Clin Exp Immunol, 133 (1), 22-29, 2003.
5. Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses.

   Isao Ishida, Atsushi Kumanogoh, Kazuhiro Suzuki, Shiro Akahani, Kazuhiro Noda and Hitoshi Kikutani

   Int Immunol, 15 (8), 1027-1034, 2003.
6. Immune semaphorins: a new area of semaphorin research.

   Atsushi Kumanogoh and Hitoshi Kikutani

   J Cell Sci, 116 (Pt 17), 3463-3470, 2003.
7. The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion.

   Caroline Moreau-Fauvarque, Atsushi Kumanogoh, Emeline Camand, Céline Jaillard, Gilles Barbin, Isabelle Boquet, Christopher Love, E Yvonne Jones, Hitoshi Kikutani, Catherine Lubetzki, Isabelle Dusart and Alain Chédotal

   J Neurosci, 23 (27), 9229-9239, 2003.
8. Roles of the semaphorin family in immune regulation.

   Atsushi Kumanogoh and Hitoshi Kikutani

   Adv Immunol, 81, 173-198, 2003.

Link

http://www.biken.osaka-u.ac.jp/