Department of Molecular Genetics

Subjects:

1. Molecular mechanisms regulating the G1/ G0 or G1/S transition and the cell cycle checkpoints in yeast and mammalian cells.
2. Molecular mechanisms controlling the cell cycle and meiosis in budding and fission yeasts.
3. Molecular mechanisms modulating the metastasis of malignant cells.
4. Development and application of new techniques for the stepwise subtraction of cDNA libraries.

Papers published in 2003

1. SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF.

   Akihiko Ito, Tomoko Jippo, Tomohiko Wakayama, Eiichi Morii, Yu-ichiro Koma, Hiroaki Onda, Hiroshi Nojima, Shoichi Iseki and Yukihiko Kitamura

   Blood, 101 (7), 2601-2608, 2003.
2. A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression.

   Akihiko Ito, Yu-Ichiro Koma, Kenji Watabe, Teruaki Nagano, Yuichi Endo, Hiroshi Nojima and Yukihiko Kitamura

   Am J Pathol, 162 (1), 81-91, 2003.
3. Localization of the PP2A B56gamma regulatory subunit at the Golgi complex: possible role in vesicle transport and migration.

   Akihiko Ito, Yu-ichiro Koma, Miwa Sohda, Kenji Watabe, Teruaki Nagano, Yoshio Misumi, Hiroshi Nojima and Yukihiko Kitamura

   Am J Pathol, 162 (2), 479-489, 2003.
4. Mammalian Mcm2/4/6/7 complex forms a toroidal structure.

   Norikazu Yabuta, Naoko Kajimura, Kouta Mayanagi, Michio Sato, Takahito Gotow, Yasuo Uchiyama, Yukio Ishimi and Hiroshi Nojima

   Genes Cells, 8 (5), 413-421, 2003.
5. Fission yeast meu14+ is required for proper nuclear division and accurate forespore membrane formation during meiosis II.

   Daisuke Okuzaki, Wataru Satake, Aiko Hirata and Hiroshi Nojima

   J Cell Sci, 116 (Pt 13), 2721-2735, 2003.
6. The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions.

   Daisuke Okuzaki, Takanori Watanabe, Seiji Tanaka and Hiroshi Nojima

   Genes Genet Syst, 78 (2), 113-126, 2003.
7. Overlapping omt1+ and omt2+ genes are required for spore wall maturation in Schizosaccharomyces pombe.

   Yoshito Kakihara, Kentaro Nabeshima, Aiko Hirata and Hiroshi Nojima

   Genes Cells, 8 (6), 547-558, 2003.

Link

http://www.biken.osaka-u.ac.jp/